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KMID : 0363420060200020019
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Journal of Korean Oriental Pediatrics
2006 Volume.20 No. 2 p.19 ~ p.34
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The Effect of Jowonsangamibang on the Growth of the Rats
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Seo Jeong-Min
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Abstract
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Objective: The purpose of this study is to find out the effect of Jowonsangamibang(JWS) on the growth of rats.
Methods: First of all, we divided male Sprague-Dawley rats into 4 groups(J1, J2, J3 and sham group). Then J1, J2 and J3 groups were administered with JWS water extracts(JWSE) once a day at a dosage 250, 500, 1,000mg/kg respectively for 3 weeks. The sham group was administered with normal saline in the same manner. And we measured body weight, amount of body weight increased, length of femur, serum GH, serum IGF-I, serum TSH and serum testosterone after each week.
Results: There were no significant changes of body weight, the level of GH, TSH, and testosterone in J1, J2 and J3 groups. The change of body weight gained was increased significantly in the J3 group compared with the sham group after 1, 2 and 3 weeks. The length of the femur was increased significantly in the J2 group after 1 week and in the J3 group after 3 weeks compared with the sham group. The level of IGF-I in the serum was increased significantly in J1, J3 after 1 week compared with the sham group.
Conclusion: According to the results above, JWS increased body weight, length of femur, serum GH, serum IGF-1 compared with the sham group. This study shows that JWS has an effect on promoting the growth of rats, thus it’s expected to treat of growth delay in children.
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KEYWORD
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Jowonsangamibang(JWS), growth, body weight, length of the femur, GH, IGF-I, TSH
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